Biomimetic synthesis of Tramadol.
نویسندگان
چکیده
Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship has been probed by (13)C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.
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عنوان ژورنال:
- Chemical communications
دوره 51 77 شماره
صفحات -
تاریخ انتشار 2015